Protesters planned to block highways leading to Israel's main international airport ahead of Netanyahu's departure to Rome for a state visit.
Police, overseen by ultranationalist National Security Minister Itamar Ben-Gvir, have pledged to prevent the disturbances. Israeli media reported the disruptions could force Netanyahu to change his travel plans to the airport.
The visit Thursday by U.S. Defense Secretary Lloyd Austin was also being affected by the protests.
An Israeli official said that Austin's meetings had been moved to a factory near the airport due to the expected disruptions.