"He has also been charged with causing a person to engage in penetrative sexual activity without consent. The charges follow a review of the evidence gathered by the Metropolitan Police in its investigation.
"The Crown Prosecution Service reminds all concerned that criminal proceedings against Mr Spacey are active and that he has the right to a fair trial.
The Met said separately that the first two counts of sexual assault date from March 2005 in London, and concern the same man, who is now in his 40s.
The third is alleged to have happened in London in August 2008 against a man who is now in his 30s. The same man is alleged to be the victim of the separate charge.
The fourth sexual assault charge is alleged to have occurred in Gloucestershire, western England, in April 2013 against a third man, who is now in his 30s.
None of the alleged victims can be identified under English law.
"Spacey is a two-time Oscar winner and known for starring roles in American Beauty, The Usual Suspects and House Of Cards.
He was previously artistic director of The Old Vic theatre in London.
