In a move widely seen as conciliatory, he made a historic trip to predominantly Muslim Türkiye later that year and prayed in Istanbul's Blue Mosque with the city's grand mufti.
The pope made a trip to the United States in 2008 where he apologised for the sexual abuse scandal, promised that paedophile priests would have to go and comforted abuse victims.
But in 2009 Benedict made one misstep after another.
The Jewish world, and many Catholics, were outraged after he lifted the excommunication of four traditionalist bishops, one of whom was a notorious Holocaust denier. Benedict later said the Vatican should have researched him better.
Jews were offended again in December 2009 when he restarted the process of putting his wartime predecessor Pius XII, accused by some Jews of turning a blind eye to the Holocaust, back on the road to sainthood after a two-year pause for reflection.
The pope prompted international dismay in March 2009, telling reporters on a plane taking him to Africa that the use of condoms in the fight against AIDS only worsened the problem.
APPOINTMENTS
At the Vatican, he preferred to appoint men he trusted and some of his early appointments were questioned.
He chose Cardinal Tarcisio Bertone, who had worked with him for years in the Vatican's doctrinal office, to be secretary of state, even though Bertone had no diplomatic experience. Bertone was later caught up in a financial scandal over the refurbishing of his Vatican apartment.
Benedict supported Christian unity but other religions criticised him in 2007 when he approved a document that restated the Vatican position that non-Catholic Christian denominations were not full churches of Jesus Christ.
Critics saw his papacy as a concerted drive to turn back the clock on reforms of the 1962-1965 Second Vatican Council, which modernised the Church in sometimes turbulent ways.
Benedict recast some Council decisions to bring them more in line with traditional practices such as the Latin Mass and highly centralised Vatican rule.
One of the themes he often returned to was the threat of relativism, rejecting the concept that moral values were not absolute but relative to those holding them and the times they lived in.
Benedict wrote three encyclicals, the most important form of papal document, including the 2007 "Spe Salvi" (Saved by Hope), an attack on atheism. The 2009 "Caritas in Veritate" (Charity in Truth) called for a rethink of the way the world economy is run.
Despite the difficulties that emerged from having two men wearing white in the Vatican, Francis developed a warm relationship with the man who was once nicknamed "the Panzer Cardinal" and said it was like having a grandfather in the house.
"He speaks little ... but with the same profundity as before," Francis once said.