The majority of people were killed in the province of El Oro while fatalities had also been recorded in Azuay, in the Andean highlands, the Ecuadorian newspaper El Comercio reported.
Ecuadorian President Guillermo Lasso called for calm and traveled to the most affected provinces of El Oro and Azuay, where he visited a hospital, among other things.
In Peru, Prime Minister Alberto Otárola said a young girl died after her home collapsed in the Tumbes region, on the border with Ecuador.
The countries lie on the Pacific Ring of Fire, an area marked by seismic upheaval with some 128 active volcanoes.
