Not alone
JUICE's array of instruments will probe Ganymede's ocean to determine its depth, distance from the surface and -- hopefully -- its composition.
The ESA's 1.6 billion euro ($1.7 billion) probe will spend eight months orbiting Ganymede, getting as close as 200 kilometres (125 miles) from the moon, all while sheltered from radiation.
It will not be the only spacecraft lurking around Jupiter.
NASA's Europa Clipper mission is scheduled to launch in October next year. It will take a quicker path to Jupiter, arriving at Europa in 2030.
If one -- or more -- of Jupiter's moons ticks all the boxes to host life, the "logical next step" would be to send a mission to land on the surface, said Cyril Cavel, JUICE project manager at manufacturer Airbus.
Although there are no plans for such a mission, which could definitively prove the existence of life outside of Earth, "that's part of the dream," he said.