Prince said the comet's next visit to the inner Solar System was expected in another 50,000 years.
But Biver said there was a possibility that after this visit the comet will be "permanently ejected from the Solar System".
Among those closely watching will be the James Webb Space Telescope. However, it will not take images, instead studying the comet's composition, Biver said.
The closer the comet is to Earth, the easier it is for telescopes to measure its composition "as the Sun boils off its outer layers", Prince said.