About 100 firefighters are battling a blaze in a nine-storey mixed-use building in London's White City.
The London Fire Brigade said 15 fire engines were in attendance at the building on Wood Lane, with the fire currently affecting floors towards the top of the building.
Wood Lane is closed to traffic and people are advised to avoid the area.
The brigade said first reports of the fire were received just after 3 am (0200 GMT) and crews from Hammersmith, North Kensington, Kensington, Chiswick and surrounding fire stations were mobilised to the scene.
Two 32-metre turntable ladders are being deployed as water towers to help extinguish the fire from height.
The cause of the fire is not known.