During Israel's brutal attacks on Gaza, which began on October 7, Haniyeh's home on Gaza City's western coast was bombed. On November 10, 2023, his grandson was martyred in an Israeli bombardment targeting a school for the displaced in Gaza City.
On April 1, 2024, Israeli police arrested one of Haniyeh's sisters on charges of communicating with Hamas members.
On April 10, 2024, Israeli forces assassinated Haniyeh's sons and grandchildren, targeting their cars during Ramadan. Haniyeh lost his sons Hazem, Amir, and Mohammed, and his four grandchildren in the attack while he was visiting injured Palestinians in Doha, Qatar.
Demonstrating immense patience, Haniyeh declared that his children sacrificed their lives for the liberation of Jerusalem and Al-Aqsa Mosque.
"All of our people, all families in Gaza have suffered great loss, and I am one of them," he said.