The nearly 50-day siege had created unrest in the Ottoman army.
Sultan Mehmet II ordered Zaganos Pasha to carry out the final attack on May 29.
Constantine XI, on the other hand, was trying to keep his realm in high spirits by organizing religious rite one after the other.
During the massive three-wave attack of the Ottomans at sunrise, Giovanni Giustiniani-Lungo, a Genoese soldier who was leading the defense was injured.
Topkapı city walls and its high tower were destroyed by artillery fire and burning gunpowder. Constantine XI along with his comrades was killed by Ottoman soldiers.
Mehmet II entered the city victorious and went to the dome of Hagia Sophia to get a view of Istanbul. He then ended the siege.