At least two people were killed and over a dozen injured in an explosion on Thursday in restive South Waziristan tribal district near the Afghan border, police said.
The explosion took place in a market of Wana, the headquarters of South Waziristan, through a remote-controlled device, local police chief Imranullah told reporters.
The injured included two policemen, he added.
No group has so far claimed responsibility for the attack, the latest in a string of similar incidents in the northwestern region in recent months.
It came amid reports that security forces are planning to launch a fresh assault on suspected militants in the tribal region, which has long been a hotbed of violence.
Pakistan has seen a surge in attacks on civilians and security forces in recent years, for which it blames what it calls "Afghan-based" militants loyal to Tehreek-Taliban Pakistan.
Kabul denies the accusation.
