Edinson Cavani scored in each half as Uruguay sent European champions Portugal and Cristian Ronaldo out of the World Cup with a 2-1 victory in an absorbing last-16 match in Sochi on Saturday.
A seventh-minute header and a curling shot in the 62nd either side of a Pepe header for Portugal in the 55th capped a man-of-the-match performance by the Paris Saint-Germain striker, who now has three goals in the tournament.
Two-time winners Uruguay now meet France in the quarter-finals in Nizhny Novgorod on Friday.
Portugal's exit following Argentina's 4-3 defeat to France earlier means the World Cup has lost both Lionel Messi and Ronaldo, the two players who have dominated the world player of the year awards for the past 10 years.
