Asma al-Assad has started treatment for early stage breast cancer, Syrian state media reported on Wednesday.
A photo published by the state news agency SANA showed Asma al-Assad, 42, hooked up to a drip smiling and sitting next to her husband Bashar al-Assad in what appeared to be a hospital room.
"Asma al-Assad begins the first stage of treatment for a malignant tumour of the breast which was discovered early," said a statement issued on the Telegram feed.
A former investment banker, Asma al-Assad was born and raised in London to Syrian parents. She married Assad in 2000.
