Set in the heart of the Çukurova (Cilician) Plain, Turkey's fourth largest city Adana has a history that goes back as far as the 7th millennium BC. While history buffs can enjoy exploring the ruins of ancient cities, nature-lovers find repose breathing the cool, clean air on the slopes and plateaus of the Taurus Mountains. Adana is one of those rare cities that have remained important throughout history. Eighteen civilizations have ruled the city with each leaving their imprint, whether a building, monument or inscription, as if trying to make their dominion eternal over the region. The ancient city of Misis is located on the banks of the Ceyhan River on the highway between Adana and Ceyhan. The nine-arch Misis Bridge across the Ceyhan River was built in the 4th century AD during the Roman Era and the Misis Mosaics Museum houses mosaics found in local excavations. The ancient city of Anazarbus (Anavarza), included in the UNESCO World Heritage Tentative List, became the capital of Cilicia in 408.